Neuregulin-1 attenuates mortality associated with experimental cerebral malaria
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چکیده
منابع مشابه
IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
Cerebral malaria (CM) is associated with a high mortality rate and long-term neurocognitive impairment in survivors. The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA)-infection reproduces several of these features. We reported recently increased levels of IL-33 protein in brain undergoing ECM and the involvement of IL-33/ST2 pathway in ECM developm...
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Malaria is one the most serious infectious diseases of humans, with ,500 million clinical cases annually. Most cases of severe disease are caused by Plasmodium falciparum, which is endemic in sub-Saharan Africa and throughout the tropics. Severe malaria is associated with a range of disease syndromes including respiratory distress, metabolic acidosis, hypoglycaemia, renal failure, and cerebral ...
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Cerebral malaria (CM) is associated with excessive inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, inflammation and T-cell migration. We hypothesized that altered S1P signaling during malaria contributes to endothelial activation and inflammation, and show that plasma S1P levels were decrea...
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BACKGROUND Cerebral malaria (CM) is responsible for most of the malaria-related deaths in children in sub-Saharan Africa. Although, not well understood, the pathogenesis of CM involves parasite and host factors which contribute to parasite sequestration through cytoadherence to the vascular endothelium. Cytoadherence to brain microvasculature is believed to involve host endothelial receptor, CD...
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ژورنال
عنوان ژورنال: Journal of Neuroinflammation
سال: 2014
ISSN: 1742-2094
DOI: 10.1186/1742-2094-11-9